AutoHotKey

WinWaitActive 

WinClose

Run("notepad.exe")
WinWaitActive("Untitled - Notepad")
Send("This is some text.")
WinClose("Untitled - Notepad")
WinWaitActive("Notepad", "Save")
;WinWaitActive("Notepad", "Do you want to save") ; When running under Windows XP
Send("!n")